Tetracyclines
Tetracyclines are a group of broad-spectrum antibiotics that are commonly used to treat a variety of bacterial infections. They are derived from the natural compound, chlortetracycline, and are effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria.
Mechanism of Action
Tetracyclines work by inhibiting bacterial protein synthesis. They do this by binding to the bacterial ribosome and preventing the attachment of aminoacyl-tRNA molecules to the ribosome-mRNA complex. This ultimately leads to the inhibition of protein synthesis, which is essential for bacterial growth and proliferation.
Uses
Tetracyclines are used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, sexually transmitted infections, and certain types of acne. They are also used in the treatment of Lyme disease, anthrax, and other atypical infections.
Side Effects
Common side effects of tetracyclines include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. They can also cause photosensitivity, so it's important to use sun protection when taking these antibiotics. In rare cases, tetracyclines can affect bone and teeth development in children, so they are generally not recommended for use in pregnant women or children under the age of 8.
Resistance
Like all antibiotics, bacteria can develop resistance to tetracyclines through various mechanisms, such as the production of efflux pumps or the acquisition of resistance genes. This highlights the importance of using antibiotics judiciously and as prescribed by a healthcare professional to minimize the development of resistance.
Study Guide
.◂Biology Worksheets and Study Guides High School. Evolution and classification
Worksheet/Answer key
Worksheet/Answer key