Tetracyclines

Tetracyclines are a group of broad-spectrum antibiotics that are used to treat a variety of bacterial infections.

Chemical Structure

Tetracyclines have a characteristic four-ring structure with a system of conjugated double bonds. This structure is responsible for their antibiotic properties.

Mechanism of Action

Tetracyclines work by inhibiting protein synthesis in bacteria. They bind to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA molecules to the A site of the ribosome, thus preventing the elongation of the peptide chain during protein synthesis.

Uses

Tetracyclines are used to treat a wide range of infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain sexually transmitted diseases. They are also used in the treatment of acne and rosacea.

Side Effects

Common side effects of tetracyclines include gastrointestinal disturbances, photosensitivity, and discoloration of teeth in children. Tetracyclines are also contraindicated in pregnancy and in children under the age of 8 due to the risk of tooth discoloration and impaired bone development.

Study Guide

1. What is the chemical structure of tetracyclines?
2. How do tetracyclines work?
3. What are the common uses of tetracyclines?
4. What are the common side effects of tetracyclines?
5. Why are tetracyclines contraindicated in pregnancy and in children under the age of 8?

Now that you have a basic understanding of tetracyclines, it's important to review and understand the information to prepare for any assessments or exams on this topic.