Macrolides

Macrolides are a class of antibiotics that are commonly used to treat various bacterial infections. They are derived from the Streptomyces bacteria and work by inhibiting bacterial protein synthesis.

Common Macrolides

Some common macrolide antibiotics include:

• Erythromycin
• Azithromycin
• Clarithromycin

Mechanism of Action

Macrolides work by binding to the 50S ribosomal subunit of bacteria, thus inhibiting the translocation of tRNA and preventing the continuation of protein synthesis. This ultimately leads to bacterial cell death.

Indications

Macrolides are used to treat a wide range of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases such as chlamydia and gonorrhea.

Side Effects

Common side effects of macrolide antibiotics include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. They can also cause allergic reactions in some individuals.

Study Guide

1. What is the mechanism of action of macrolides?
2. Provide examples of common macrolide antibiotics.
3. What are the indications for using macrolides?
4. What are the common side effects of macrolides?

Remember to always consult a healthcare professional for specific medical advice and treatment.