Macrolides: Explained

Macrolides are a class of antibiotics that are used to treat a variety of bacterial infections. They work by inhibiting the protein synthesis in bacteria, thus preventing them from growing and multiplying.

Mechanism of Action

Macrolides act by binding to the 50S subunit of the bacterial ribosome, which inhibits the translocation step of protein synthesis. This ultimately leads to the prevention of bacterial growth and reproduction.

Common Macrolide Antibiotics

• Erythromycin
• Azithromycin
• Clarithromycin

Indications for Use

Macrolide antibiotics are commonly used to treat respiratory tract infections, skin infections, and sexually transmitted diseases such as chlamydia and gonorrhea.

Side Effects

Common side effects of macrolides include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. They may also cause liver toxicity and allergic reactions in some individuals.

Study Guide: Macrolides

Definition

Define macrolides and explain their mechanism of action.

Examples

List at least three common macrolide antibiotics and their indications for use.

Side Effects

Discuss the potential side effects of macrolide antibiotics and how they may impact patients.