Tetracyclines are named after their four-ring structure. They work by inhibiting bacterial protein synthesis. They bind to the bacterial ribosome, preventing the attachment of aminoacyl-tRNA molecules to the RNA-ribosome complex. This ultimately inhibits protein synthesis in the bacteria, leading to their inability to grow and replicate.
Common Tetracyclines
Tetracycline
Doxycycline
Minocycline
Usage and Considerations
Tetracyclines are usually taken orally, either with or without food, but it's important to follow the specific instructions provided by the healthcare provider. They should not be taken with dairy products or antacids, as these can interfere with the absorption of the medication. Additionally, tetracyclines should not be used in children under the age of 8 or in pregnant women, as they can affect bone and tooth development in children and the developing fetus.